objective viewpoint based on the verification results is indispensable when considering the efficacy of hydrogen.So far, there have been more than 1500 reports released in the world on hydrogen effects. We hereby only introduce clinical trials.

List of research papers

Ohsawa et al. published a seminal paper on Natural Medicine (13:688-694, 2007) that demonstrated physiological and therapeutic effects of molecular hydrogen,
and became the milestone of Molecular Hydrogen Medicine.

Based on Ichihara et al. Medical Gas Research 2015 5:12 doi:10.1186/s13618-015-0035-1,
clinical trials that have been registered in Japan as of June, 2015 are below.

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Hydrogen Therapy in Cancer Management:

A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Main contents summary: Cancer remaAins a challenging target to cure, with presAent therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summarises the findings from various articles on the mechanism, treatment outcomes, and overall effectiveness of H2 therapy on cancer management.

H2 Inhibits the Formation of Neutrophil Extracellular Traps（Preclinical Research) :

conducted by JACC: Basic to Translational Science in 2022. H2 therapy is potentially a new therapeutic strategy for inflammatory　diseases involving NETs associated with excessive neutrophil activation.

Interstitial Cystitis :

conducted by Koshinkai Hosp. in 2008

Impaired glucose tolerance and impaired fasting glycaemia:

conducted by Digestive tract internal medicine, Kyoto Prefectural University of Medicine in 2008

Mild cognitive impairment :

conducted by Neuropsychiatry, Tsukuba Univ. in 2009

Chronic hemodialysis :

conducted by Nephrology, Fukushima Medical University in 2011

Acute cerebral infarction :

conducted by Neurosurgery, Self Defense Medical College in 2011

Normal adults :

conducted by Faculty of Health Science, kyorin Univ. in 2011

Acute myocardial infarction :

conducted by Cardiology, Keio Univ. in 2011

Parkinson’s disease :

conducted by Neurology, Juntendo Univ. in 2012

Multiple system atrophy, Progressive supranuclear palsy :

conducted by Neurology, Juntendo Univ. in 2012

Parkinson’s disease :

conducted by Neurology, Juntendo Univ. in 2013

Chronic obstructive pulmonary disease :

conducted by Respiratory Medicine, Juntendo Univ. in 2013

Hepatitis and liver cirrhosis :

conducted by Gastroenterology and Hepatology, Okayama Univ. in 2013

Post cardiac arrest syndrome :

conducted by Emergency and Critical care medicine, Keio Univ. in 2014

Eye disease :

conducted by Ophthalmology, Nippon Medical school in 2014

Acute myocardial infarction :

conducted by Cardiology, National Center for Global Health and Medicine in 2014

Subarachnoid hemorrhage:

conducted by Neurosurgery, Self Defense Medical College in 2014

Lung transplantation:

conducted by General thoracic surgery, Osaka Univ. in 2014

Retinal artery occlusion:

conducted by Ophthalmology, Nippon Medical school in 2014

Type 2 diabetes mellitus:

conducted by Tokyo Metropolitan Institute of Gerontology in 2015

Hydrogen treatment method was approved as Advanced Medicine B by the Ministry of Health, Labor and Welfare on November 30, 2016, which is promoted by Dr. Matoaki Sano (M.D., PhD. Director of The Center for Molecular Hydrogen Medicine, Keio University) et al.

The following two articles are written by Israeli professor Sergei M. Ostojic, MD, PhD.

University of Novi Sad · Department of Biomedical Sciences, Faculty of Sport and Physical Education

“HYDROGEN FOR METABOLIC FITNESS IN OVERWEIGHT WOMEN” (published in Irish Journal of Medical Science (1971-) 187, 85-89 (2018)) In this double blind, placebo-controlled trial, we found that hydrogen-generating minerals reduced body fat percentage and arm fat index in middle-aged overweight women; this was accompanied by a significant drop in serum triglycerides and fasting serum insulin after H2 administration.

The pilot study “HYDROGEN INHALATION IN ELDERLY” (published in European Geriatric Medicine.9, 729-730 (2018)) Short-term H2 inhalation positively affected the American Heart Association (AHA)cardiovascular risk scores, health-related physical fitness, and cardiometabolic biomarkers in men and women aged 65 years or older. 

Dr. Junji Akagi, Department of Surgery, Tamana Regional Health Medical Center, released the article “Hydrogen gas restores exhausted CD8T cells in patients with advanced colorectal cancer to improve prognosis” in 2018. The patients inhaled hydrogen gas for 3h/day at their own homes and received chemotherapy at the Tamana Regional Health Medical Center. The results suggested that hydrogen gas reverses imbalances toward PD‑1+ CD8+ T cells to provide an improved prognosis.

Hydrogen gas has been researched as a method for COVID-19 treatment. Fuxun Yang†, Ruiming Yue†, Xiaoxiu Luo, Rongan Liu* and Xiaobo Huang, Department of Critical Care Medicine, Sichuan Provincial People’s Hospital, Chengdu, released article “Hydrogen: A Potential New Adjuvant : Therapy for COVID-19 Patients” HYPOTHESIS AND THEORY doi:10.3389/fphar.2020.543718. Also Hydrogen and oxygen mixed gas as a therapy for COVID-19 Patients has been approved by FDA China, which had a significant impact in hydrogen medical field.

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